Absolutely! GenStone artificial siding only requires a clean, dry substrate, such as OSB, plywood, concrete, or existing siding providing the surface is flat such as RB&B, Textured 1-11, or any hardboard panel siding. Featured below is a home remodel where the individual installed GenStone over existing white brick.
There is also is a guide below that goes step by step through the process of how to apply GenStone to existing brick.
*Photo credit to ENS Home Solutions, LLC in Pennsylvania